All Leading Causes of Death

The leading cause of death varies by age group and sex. While preventable injuries are the third leading cause of death among males, the rank drops to seventh among females.

For infants younger than 1, preventable injuries were the fourth leading cause of death in 2022, but they climb to the leading cause starting with the 1 to 4 age group all the way through the 35 to 44 age group. Preventable injuries become the third leading cause of death among the 45 to 64 age groups. Natural causes of death become more prevalent and the rank of preventable injury-related deaths drops in older age. Among those in the 65 to 74 and older age groups, preventable injuries drop out of the top five leading causes of death.

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Source: National Safety Council analysis of Centers for Disease Control and Prevention, National Center for Health Statistics. National Vital Statistics System, Mortality 2018-2022 on CDC WONDER Online Database, released in 2024. Data are from the Multiple Cause of Death Files, 2018-2022, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed at