All Leading Causes of Death

The leading cause of death varies by age group and sex. While preventable injuries are the fourth leading cause of death among males, the rank drops to six among females.

For infants younger than 1, preventable injuries were the fourth leading cause of death in 2021, but they climb to the leading cause starting with the 1 to 4 age group all the way through the 35 to 44 age group. Preventable injuries become the fourth leading cause of death among the 45 to 64 age groups. Natural causes of death become more prevalent and the rank of preventable injury-related deaths drops in older age. Among those in the 65 to 74 and older age groups, preventable injuries drop out of the top five leading causes of death.

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How to Use Injury Facts® Charts and Tables

Source: National Safety Council analysis of National Center for Health Statistics – Mortality Data for 1999-2021 as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program, Web-based Injury Statistics Query and Reporting System (WISQARS).