Preventable drug overdose deaths decreased 25% in 2024 (to 72,697). Despite this improvement, preventable drug overdose deaths have increased 552% since 1999 (from 11,155). These deaths represent 92% of the total 79,384 drug overdose deaths in the United States, which also include suicide, homicide, and undetermined intents.
Because Injury Facts focuses on preventable injury statistics, this page concentrates on preventable drug overdose trends. The interactive chart analyzes preventable drug overdose deaths by default. However, users can analyze either preventable or all injury intents. To analyze total drug deaths, select “All” in the intent field. When comparing drug overdose deaths to the other preventable causes of death data in Injury Facts (like motor-vehicle crashes, falls, or choking), preventable drug overdose death estimates are recommended.
The chart allows you to compare fatality trends by drug type, age, and gender. When comparing deaths by drug type, multiple drugs are often listed for one death. Because of this, the fatality counts by drug type are not mutually exclusive and should not be added together to calculate totals.
The majority of preventable drug overdose deaths (70%) involve opioids, totaling 51,088 in 2024. Opioid drugs include both prescription and illicit drug categories. The drug category most frequently involved in preventable opioid overdoses and growing at the fastest pace is “synthetic opioids other than methadone.” This category includes fentanyl, fentanyl analogs, and tramadol. The fentanyl category of opioids accounted for 45,917 preventable deaths in 2024, representing a 34% decrease from the 2023 total of 70,060.
A non-opioid (the Psychostimulants category that includes methamphetamines) accounted for the second highest number of preventable drug deaths, claiming 27,954 lives in 2024 (a 18% increase from the 33,965 deaths in 2023).
Cocaine overdoses accounted for 21,275 deaths in 2024, representing a 25% decrease from 2023.
The opioid category that includes morphine, oxycodone, and hydrocodone (natural and semisynthetic opioids) was involved in 6,738 preventable deaths in 2024, a 23% decrease from 2023.
The chart also allows you to explore overdose death trends among a few other non-opioid drugs, including benzodiazepines, cocaine, and cannabis.
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